* Babel - Gustavo Santaolalla [Concord Records]
* Blood Diamond - James Newton Howard [Varese Sarabande]
* The Departed - Howard Shore [New Line Records]
* Happy Feet - John Powell [Warner Sunset/Atlantic]
* Pan's Labyrinth - Javier Navarrete [Milan Records]
* Ratatouille - Michael Giacchino [Walt Disney Records]
# Across The Universe (Various Artists) - T Bone Burnett, Elliot Goldenthal & Tessa Gohl, producers [Interscope Records]
# Dreamgirls (Beyoncé Knowles, Jennifer Hudson & Anika Noni Rose) Harry Mason, Jr., Randy Spendlove, Matt Sullivan & Damon Thomas, producers [Music World Music/Sony Urban Music/Columbia/Sony Music Soundtrax]
# Hairspray (Various Artists) Marc Shaiman, producer [New Line Records]
# Love (The Beatles) George Martin & Giles Martin, producers [Apple Records/Capitol Records]
# Once (Glen Hansard & Marketa Irglova) Glen Hansard, producer [Canvasback/Columbia/Sony Music Soundtrax]
# Falling Slowly (Once) Glen Hansard & Marketa Irglova, songwriters (Glen Hansard & Marketa Irglova) [Canvasback/Columbia/Sony Music Soundtrax; Publisher: Copyright Control]
# Guaranteed (Into The Wild) Eddie Vedder, songwriter (Eddie Vedder) [J Records; Publisher: Monkey Wrench]
# Love You I Do (Dreamgirls) Siedah Garrett & Henry Krieger, songwriters (Jennifer Hudson) [Music World Music/Sony Urban Music/Columbia/Sony Music Soundtrax; Publishers: Miroku Music/Williamson Music/Black Chick Music Publishing, SKG Songs]
# The Song Of The Heart (Happy Feet) Prince Rogers Nelson, songwriter (Prince) [Warner Sunset/Atlantic; Publishers: Controversy Music/Universal Music Corp.]
# You Know My Name (Casino Royale) David Arnold & Chris Cornell, songwriters (Chris Cornell) [Suretone/Interscope Records; Publishers: Disappearing One/EMI April Music/UA Music/New Columbia Pictures Music, Thrust/Magnum Music/Bucks Music/United Lion Music/Colpix Music]
L'américain Philip Glass est également nominé pour la meilleure pièce intrumentale de l'année avec "I Knew Her" tiré de sa bande originale composée pour le film Notes On A Scandal.
Interview B.O : Audrey Ismaël (Le Royaume, de Julien Colonna)
Interview B.O : Audrey Ismaël (Diamant brut, de Agathe Riedinger)